Premise: Refugees flee through space to make a new home. (It turned out that the refugees were 'the human race', and the story focused almost entirely on the journey rather than settlement or the opening disaster.)

No: strong AI, teleportation, psychics, anthro aliens, dinosaurs.
Yes: interplanetary commerce, lava-based technology

Players: Nathan, Drew, Alex, Sam

The main theme here was the constant inability of humans to avoid crippling factionalism. Early on, an entire subculture of space-pioneering humans, the Wayfolk, developed; it was implied that this ethnic division underlay a lot of the later conflicts. On the exodus, at first powers were divided between the military and the pseudo-republican clan system, but fairly early on the Black Water Corporation was founded, initially as a secret society but slowly rising to more visible influence. Humanity ended up splitting into a Black Water-led faction and a faction mostly derived from the military influence (and political ineptitude) of Delilah Carter, captain of the fleet flagship UIPC Unity.

Most of the action focused around these splits, near the middle of the timeline; the latter half of the story in particular was rather fuzzy.

Humans also encountered a number of alien races, most of which were very alien; the warlike Jirax were basically rocks that communicated by off-gassing, the Consortium of Trow were creepy insect-like things with body-fluid-based social niceties who would only trade in indentured servants, the Zykoo were small humanoids who were mostly just horribly confused by how given humans were to squabbling. And then there were the sentient planets and the eyeball moon around the lung planet. We never quite worked out what the deal was with that.

This was a decent game of Microscope, but not really a standout one, and had rather more significant loose ends floating around than you normally get.